Background: We have investigated the relationship between atopic status and long-term occupational exposure to latex proteins or methyl diethyl diisocyanate (MDI) as high and low molecular weight asthma-inducing agents, respectively. Methods. This study is based on retrospective analyses of two groups of symptomatic outpatients: 184 healthcare workers with latex exposure and 156 workers with isocyanate (MDI) exposure. We analysed atopic and non-atopic subgroups according to exposure duration and the frequencies of specific sensitization. Results: 45% of the healthcare subgroup specifically sensitized to latex were atopic, whereas in the non-sensitized healthcare subgroup only 26% were atopic. On the other hand, subjects specifically sensitized to MDI were rarely atopic (only 15%), whereas in the subgroup non-sensitized to MDI atopy was present in 38%. After prolonged durations of exposure, the proportion of atopics was further elevated in most healthcare subgroups but it decreased in the MDI-exposed subjects. Conclusions: We hypothesize that latex proteins as sensitizing agents might promote the development of atopy, whereas exposure to the low molecular weight MDI might inhibit the atopic status. © 2013 Baur and Barbinova; licensee BioMed Central Ltd.
CITATION STYLE
Baur, X., & Barbinova, L. (2013). Occupational airborne exposure, specific sensitization and the atopic status: Evidence of a complex interrelationship. Journal of Occupational Medicine and Toxicology, 8(1). https://doi.org/10.1186/1745-6673-8-2
Mendeley helps you to discover research relevant for your work.