The Effect of Dandang Gendis (Clinacanthus nutans) Extracts on Blood Glucose Levels in Wistar Rats Diabetes Mellitus Model

Abstract

Diabetes Mellitus refers to a disease indicated by hyperglycemia due to abnormality in either insulin secretion or action, or both. Dandang gendis leaves (Clinacanthus nutans) is known to contain antioxidants, which is reported to be able to lower blood glucose levels. The present study aimed to find out the effect of giving the extract of C. nutans on the blood glucose of Wistar rat as a diabetic model. Thirty rats that met the criteria were divided into five groups; they were then induced by hyperglycemia using Streptozocin (STZ) 50 mg/kg. Two days after the induction, the rats were treated using C. nutans extract with the dosage of K1 (75 mg/kgBW), K2 (150 mg/kgBW), and K3 (300 mg/kgBW), then they are compared to K0 (CMC-Na as the control) and K4 (metformin as standard medication) for fourteen days. The most significant decrease of blood glucose was found in the group that was treated using 75mg/kg of C. nutans extract, compared to the K0, K2, K3, and K4.