Associative memory model of hippocampus CA3 using spike response neurons

Abstract

One of the functional roles of the hippocampus is the storage and recall of associative memories. The hippocampus CA3 region has been hypothesized to function as an associative network. Dual oscillations have been recorded in brain regions involved in memory function in which a low frequency theta oscillation is subdivided into about seven subcycles of high frequency gamma oscillation. In this paper, the computational model of hippocampus CA3 proposed by Jensen et al. is realized using the Spike Response Model (SRM). The SRM-based network is able to demonstrate the same memory storage capability with added simplicity and flexibility. Different short term memory items are encoded by different subset of principal neurons and long term associative memory is maintained in the synaptic modifications of recurrent collaterals. The formation of associative memory is demonstrated in simulations. © 2011 Springer-Verlag.