Abstract
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2- expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
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CITATION STYLE
Matsuyama, S., Nao, N., Shirato, K., Kawase, M., Saito, S., Takayama, I., … Takeda, M. (2020). Enhanced isolation of SARS-CoV-2 by TMPRSS2- expressing cells. Proceedings of the National Academy of Sciences of the United States of America, 117(13), 7001–7003. https://doi.org/10.1073/pnas.2002589117
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