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FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

Journal of Translational Medicine (2021) 19(1)
DOI: 10.1186/s12967-021-02754-0
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Abstract

Background: Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.402C

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Secchi, C., Benaglio, P., Mulas, F., Belli, M., Stupack, D., & Shimasaki, S. (2021). FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor. Journal of Translational Medicine, 19(1). https://doi.org/10.1186/s12967-021-02754-0

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