CCN2 is a profibrotic matricellular protein. CCN2 directly promotes cell adhesion and indirectly promotes fibrosis by activating adhesive signaling in response to growth factors, cytokines, and extracellular matrix. The following protocols will allow the direct assessment of other CCN family members in these processes.
CITATION STYLE
Hutchenreuther, J., Leask, A., & Thompson, K. (2017). Studying the CCN proteins in fibrosis. In Methods in Molecular Biology (Vol. 1489, pp. 423–429). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6430-7_35
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