The estrogen stimulated rat uterus serves as a useful model to examine steroid resistance during aging. This system exhibits receptor loss, impaired stimulation of RNA polymerase II and defects in nuclear translocation (or enhanced association) of receptor-estradiol complexes. All of these defects appear to contribute in part to decreased estrogen responsiveness of the senescent rodent uterus.
CITATION STYLE
Roth, G. S. (1986). Altered estrogen action in the senescent rat uterus: a model for steroid resistance during aging. Advances in Experimental Medicine and Biology. https://doi.org/10.1007/978-1-4684-5101-6_23
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