One of the most important roles of Sirtuins is to ensure the maintenance of genome integrity under stress conditions. In this chapter, we provide a methodology to study this role of Sirtuins at two different levels: detection of genomic instability (with the Neutral Comet Assay) and study of Sirtuin dynamics in chromatin under stress conditions (by isolating insoluble chromatin fractions). © 2013 Springer Science+Business Media, LLC.
CITATION STYLE
Martínez-Redondo, P., & Vaquero, A. (2013). Methods to study the role of sirtuins in genome stability. Methods in Molecular Biology, 1077, 273–283. https://doi.org/10.1007/978-1-62703-637-5_18
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