FRI0443 CLINICAL CHARACTERISTICS AND RELATED FACTORS OF COMMON RHEUMATIC DISEASES COMPLICATED WITH TUBERCULOSIS INFECTION

Abstract

Objective: To explore the clinical characteristics and high risk factors of common systemic rheumatism complicated with tuberculosis infection (TB). Methods: A total of 3,906 cases of RA, SLE, and SS diagnosed in the People's Hospital of Sichuan Province from January 2007 to January 2017 were collected with carefully exclusion with other infectious diseases and neoplastic disease. One hundred and five patients with TB were included as infection group, including 42 cases of RA, 41 cases of SLE, and 22 cases of SS. In the control group, 84 patients with RA, 82 patients with SLE, and 44 patients with SS were randomly selected from the corresponding rheumatoid non‐infected patients hospitalized during the same period. Results: Fever was the most common symptom among 42 cases of RA, 41 cases of SLE, and 22 cases of SS with TB, accounting for 83.3%, 92.7%, and 68.2%, respectively. For 41 cases of SLE and 22 cases of SS with TB, the proportion of pulmonary was 46.3%, 59.01%, respectively. In TB infection group, 27 cases of RA, 21 cases of SLE, and 13 cases of SS with TB had two or more chest CT findings,accounting for 59%, 57%, 62%, respectively. The daily average dose of hormones within 1 year in TB infection group was higher than that in the control group (P < 0.05). For SLE patients, lower counts of CD4 + TL were found in TB infection group (P < 0.05), while no such differences were found in RA and SS group. Conclusion: Patients with RA who have TB infection are mainly pulmonary TB. For SLE and SS patients, the chance of pulmonary tuberculosis and extra‐pulmonary tuberculosis is similar. Symptoms of RA, SLE, SS with TB, such as fever, cough, weight loss, fatigue, are similar with the primary disease or other infection. Daily average dose of hormone within one year may be a common risk factor for RA, SLE and SS patients with TB. Decreased CD4 + TL may also be a risk factor for SLE patients with TB.