Fibrinogen γ chain functions

Abstract

This review covers the functional features of the fibrinogen γ chains including their participation in fibrin polymerization and cross-linking, their role in the initiation of fibrinolysis, their binding and regulation of factor XIII activity, their interactions with platelets and other cells, and their role in mediating thrombin binding to fibrin, a thrombin inhibitory function termed 'antithrombin I'. © 2003 International Society on Thrombosis and Haemostasis.