Abstract
An extended-spectrum β-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. bla IBC-2 was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these β-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-β-lactams.
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CITATION STYLE
Mavroidi, A., Tzelepi, E., Tsakris, A., Miriagou, V., Sofianou, D., & Tzouvelekis, L. S. (2001). An integron-associated β-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum β-lactamase IBC-1. Journal of Antimicrobial Chemotherapy, 48(5), 627–630. https://doi.org/10.1093/jac/48.5.627
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