Mitochondrial gene expression in diabetes mellitus: Effect of nutrition

Abstract

Diabetes mellitus is a collection of genetic diseases that share a common phenotype: Glucose intolerance. The genetic origins of this disease are being widely investigated. An estimated 0.1-9% of the population with diabetes has the disorder owing to one or more mutations in the mitochondrial genome. Diet can affect the expression of the genome as well as the function of its gene products. The antioxidant nutrients serve to protect this very vulnerable genome from oxidative damage. These nutrients may affect mitochondrial DNA transcription and nutrients that affect membrane fluidity affect the function of the gene products.