Differential persistence of neutralizing antibody against SARS-CoV-2 in post immunized Bangladeshi population

3Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Development of effective vaccines have been immensely welcomed by the world to prevent the transmission of SARS-CoV-2. However, the duration and clinical implications of antibody-mediated natural immunity in SARS-CoV-2 have not been adequately elucidated alongside some other immune system transforming factors. In a cohort study, we measured NAb titer following the 2nd immunization dosage of the CoviShield (AZD1222) vaccine. The enzyme-linked immunoassay was used to look for SARS-CoV-2—specific NAb. We measured NAb at 30 days after the 2nd dosage of immunization and > 96% titer was detected in 42.9% of subjects, but only 5.1% of subjects retained the same level after 180 days. The median NAb titer dropped significantly, from 92% at 30 days to 58% at 180 days (p < 0.001). Besides, there were significant differences observed in NAb titer after 180 days by age, sex, COVID-19 infection, tobacco use, and asthma patients. However, SARS-CoV-2 infection along with two dosages of immunization upheld NAb titer (p < 0.001) even at the end of the study period.

References Powered by Scopus

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

6490Citations
N/AReaders
Get full text

WHO declares COVID-19 a pandemic

5377Citations
N/AReaders
Get full text

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

3607Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Predictors of long-term neutralizing antibody titers following COVID-19 vaccination by three vaccine types: the BOOST study

12Citations
N/AReaders
Get full text

Combined detection of SARS-CoV-2 neutralizing antibodies and specific IgG in plasma based on SERS magnetic sensor

1Citations
N/AReaders
Get full text

Antibody Response after Homologous and Heterologous Prime–Boost COVID-19 Vaccination in a Bangladeshi Residential University Cohort

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Roy, D., Rahman, M. M., Chaity, A. S., Reza, M. A., & Haque, A. (2022). Differential persistence of neutralizing antibody against SARS-CoV-2 in post immunized Bangladeshi population. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-18302-9

Readers over time

‘22‘23‘2401234

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

50%

Professor / Associate Prof. 2

33%

Researcher 1

17%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

40%

Nursing and Health Professions 1

20%

Social Sciences 1

20%

Engineering 1

20%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 111

Save time finding and organizing research with Mendeley

Sign up for free
0