Alterations of individual thalamic nuclei volumes in patients with migraine

Abstract

Background: The aim of this study is to investigate the alterations of thalamic nuclei volumes and the intrinsic thalamic network in patients with migraine. Methods: We enrolled 35 patients with migraine without aura and 40 healthy controls. All subjects underwent three-dimensional T1-weighted imaging. The thalamic nuclei were segmented using the FreeSurfer program. We investigated volume changes of individual thalamic nuclei and analyzed the alterations of the intrinsic thalamic network based on volumes in the patients with migraine. Results: Right and left thalamic volumes as a whole were not different between the patients with migraine and healthy controls. However, we found that right anteroventral and right and left medial geniculate nuclei volumes were significantly increased (0.00985% vs. 0.00864%, p = 0.0002; 0.00929% vs. 0.00823%, p = 0.0005; 0.00939% vs. 0.00769%, p < 0.0001; respectively) whereas right and left parafascicular nuclei volumes were decreased in the patients with migraine (0.00359% vs. 0.00435%, p < 0.0001; 0.00360% vs. 0.00438%, p < 0.0001; respectively) compared with healthy controls. The network measures of the intrinsic thalamic network were not different between the groups. Conclusions: We found significant alterations of thalamic nuclei volumes in patients with migraine compared with healthy controls. These findings might contribute to the underlying pathogenesis of the migraine.