Life-Extending Effect of Phytochemicals in Drosophila

Abstract

Plant-derived compounds known as phytochemicals have attracted the attention of biologists as well as the general public for their ability to improve quality and quantity of life. Several phytochemicals have been found to exert beneficial effects in this regard, including inhibition of aging and extending the life spans of experimental animals such as yeast, worms, flies, and mice. Drosophila melanogaster is a particularly effective model system for evaluating anti-aging compounds. This insect is suitable for aging research since it has a rapid generation time and short life span. In this chapter, we review typical phytochemicals such as resveratrol, curcumin, and catechin that extend the life span of Drosophila melanogaster as well as discuss the molecular mechanisms underlying this effect.