PREPARATION AND EVALUATION OF PIROXICAM - PLURONIC SOLID DISPERSIONS

Abstract

With an objective of enhancing the dissolution rate of piroxicam (PXM), solid dispersions(SDs) of piroxicam were prepared using different grades of pluronic F-68 (Pl. F-68), pluronicF-98 (Pl. F-98), and pluronic F-127 (Pl. F-127) adopting the solvent evaporation technique.The solid dispersions were prepared at different (drug: polymer) ratio (1:1, 1:3 and 1:5).Piroxicam- pluronic solid dispersions were investigated by inferared spectroscopy (IR), x-raydiffraction (XRD) and differential scanning calorimetry (DSC). The IR spectra prevailed nochemical interaction between the drug and copolymer. The powder x-ray diffraction (XRD)patterns and differential scanning calorimetry (DSC) thermograms demonstrated thatpiroxicam was existed in a solid solution state in the SD. Phase diagram for solid dispersion ofpiroxicam in pluronic F-98 indicated that the solid solution of piroxicam was obtained at aconcentration of PXM less than 35% in the SD. The stability study was carried out for the soliddispersion prepared at 1:1 (piroxicam/ Pl. F-98) at 40 ° for 40 weeks prevailed that; the drug isstable during the storage period in the dispersion. The solubility study of piroxicam was carriedout at different concentrations of pluronics, also the dissolution rate of the drug was improvedeither by physical mixture or the solid dispersions.