SP642ASSOCIATION OF OVERHYDRATION AND MUSCLE WASTING MEASURED BY BIOELECTRICAL IMPEDANCE ANALYSIS AND MORTALITY IN HEMODIALYSIS

Abstract

INTRODUCTION AND AIMS: Assessment of body water status in hemodialysis patents is very important. Overhydration in hemodialysis is associated with generalized edema, cardiovascular complications, hypertension. The aim of this study was determine the factors correlated mortality of hemodialysis patients with assessment to the body muscle mass and body water status, using bioelectrical impedance analysis (BIA). METHODS: This study involves 93 patients who underwent hemodialysis between January 2010 and May 2015 at Bundang CHA medical center. Medical records including laboratory data such as serum albumin, C-reactive protein(CRP), lipid profile etc. and BIA (InBody S10) measure data were reviewed retrospectively until June 2017. RESULTS: Eleven of total 93 patients were expired until May 2017. The overall survival group was younger and showed lower CRP level, higher albumin level and lower extracellular water/total body water(ECW/TBW) ratio than the expired patient group. The correlation results between BIA parameters and albumin revealed positive correlation with soft lean mass, fat free mass(FFM), total body water, intracelluar water and negative correlation with ECF/TBWratio, TBW/FFM. Kaplan-Meier survival analysis revealed that overhydration group (ECW/TBW>0.4) had higher mortality than nonoverhydration group(ECW/TBW >= 0.4). CONCLUSIONS: In hemodialysis patients, overhydration is important factor for mortality and BIA could be a reliable modality for assessment of overhydration. We suggest that overhydration is more risk factor for mortality than muscle wasting in hemodialysis patients.