Abstract
Neural stem cells represent a heterogeneous population of mitotically active, self-renewing and multipotent cells of both the developing and the adult central nervous system (CNS) showing complex patterns of gene expression that may vary in both space and time. Endogenous stem cells residing within CNS germinal niches might concur to nervous system repair owing to their ability to drive neurogenesis and gliogenesis during adulthood. Nevertheless, self-renewal, proliferation, migration and differentiation of CNS stem cells may significantly vary upon different types (e.g. acute vs chronic, focal vs multifocal) of CNS injury. In this chapter we address several aspects of neural stem cell pathophysiology. © Springer Science+Business Media, LLC 2010.
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Pluchino, S., Bacigaluppi, M., Brini, E., Butti, E., Cossetti, C., Cusimano, M., … Martino, G. (2010). The neural stem cells. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems (pp. 71–78). Springer New York. https://doi.org/10.1007/978-1-60327-153-0_4
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