Mucosal-associated invariant T (MAIT) cells recognize intermediates of the vitamin B2 biosynthetic pathway present in a variety of bacteria, presented by the monomorphic MR1 molecules. Because of their central role in shaping adaptive immunity through interaction with dendritic cells (DCs) and B cells, their manipulation can be of translational relevance. We describe a method to routinely isolate and maintain MAIT cells from peripheral blood and to investigate their activity using DC as targets.
CITATION STYLE
Salio, M., & Cerundolo, V. (2020). Interactions Between MAIT Cells and Dendritic Cells. In Methods in Molecular Biology (Vol. 2098, pp. 125–139). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0207-2_8
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