Risk of mature B-cell neoplasms and precursor conditions after joint replacement: A report from the Haematological Malignancy Research Network

5Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Associations between previous joint replacement and B-cell lymphoid malignancies have been reported, but despite numerous reports, associations with the disease subtypes have received little attention. Using a UK-based register of haematological malignancies and a matched general population-based cohort, joint replacements from linked hospital inpatient records were examined. Cases diagnosed 2009–2015 who were aged 50 years or more were included; 8,013 mature B-cell neoplasms comprising myeloma (n = 1,763), diffuse large B-cell lymphoma (DLBCL, n = 1,676), chronic lymphocytic leukaemia (CLL, n = 1,594), marginal zone lymphoma (MZL, n = 957), follicular lymphoma (FL, n = 725) and classical Hodgkin lymphoma (CHL, n = 255), together with monoclonal gammopathy of uncertain significance (MGUS, n = 2,138) and monoclonal B-cell lymphocytosis (MBL, n = 632). Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated relative to 10 age- and sex-matched controls using conditional logistic regression. Having had a joint replacement before diagnosis was associated with myeloma (OR = 1.3, 95% CI 1.1–1.5, p = 0.008) and MGUS (OR = 1.3, 95% CI 1.1–1.5, p < 0.001). Excluding replacements in the year before diagnosis, the MGUS risk remained, elevated where two or more joints were replaced (OR = 1.5, 95% CI 1.2–2.0, p = 0.001), with hip (OR = 1.2, 95% CI 1.0–1.5, p = 0.06) or knee replacements (OR = 1.5, 95% CI 1.2–1.8, p < 0.001). Associations with CHL and two or more replacements (OR = 2.7, 95% CI 1.3–5.6, p = 0.005) or hip replacements (OR = 1.9, 95% CI 1.0–3.4, p = 0.04); and between DLBCL and knee replacements (OR = 1.3, 95% CI 1.0–1.6, p = 0.04) were also observed. Our study reports for the first time a relationship between joint replacements and MGUS; while absolute risks of disease are low and not of major public health concern, these findings warrant further investigation.

References Powered by Scopus

Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003

818Citations
N/AReaders
Get full text

Incidence of haematological malignancy by sub-type: A report from the Haematological Malignancy Research Network

525Citations
N/AReaders
Get full text

The epidemiology of revision total knee and hip arthroplasty in England and Wales: A comparative analysis with projections for the United States. a study using the national joint registry dataset

447Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Site-specific cancer risk following cobalt exposure via orthopedic implants or in occupational settings: A systematic review and meta-analysis

11Citations
N/AReaders
Get full text

Cohort Profile Update: The Haematological Malignancy Research Network (HMRN) UK population-based cohorts

10Citations
N/AReaders
Get full text

Health impact of monoclonal gammopathy of undetermined significance (MGUS) and monoclonal B-cell lymphocytosis (MBL): Findings from a UK population-based cohort

8Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kane, E., Painter, D., Smith, A., Lamb, M., Oliver, S. E., Patmore, R., & Roman, E. (2020). Risk of mature B-cell neoplasms and precursor conditions after joint replacement: A report from the Haematological Malignancy Research Network. International Journal of Cancer, 147(3), 702–708. https://doi.org/10.1002/ijc.32765

Readers' Seniority

Tooltip

Researcher 3

100%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

67%

Nursing and Health Professions 1

17%

Psychology 1

17%

Save time finding and organizing research with Mendeley

Sign up for free