Comparison of the acute toxicity of clioquinol, histamine, and chloroform in different strains of mice

Abstract

The oral LD50's of clioquinol, histamine and chloroform and the intravenous LD50 of histamine were determined separately in male and female mice of the Tif:MAGf (SPF), Tif:MF2f (SPF), C3H/Tif Bomf DBA/2/J Bomf, C57B1/6J/Bomf and A/J Bomf strains. Mice of the Tif:MAGf (SPF) outbred strain and the Tif:MF2f (SPF) hybrids tended to be more resistant than the inbred strains, with exception of C57B1/6J/Bomf, which proved least susceptible to the lethal effects of the tested preparation. The toxicity of chloroform was more pronouned in the males than in the females, and C3H/Tif Bomf proved more susceptible than all other strains. The toxicity of clioquinol and histamine was not related to sex.