G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity. © 2009 Macmillan Publishers Limited.
CITATION STYLE
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009, May 21). The structure and function of G-protein-coupled receptors. Nature. https://doi.org/10.1038/nature08144
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