Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.
CITATION STYLE
Conceição, E. C., Salvato, R. S., Gomes, K. M., Dos Santos Guimarães, A. E., Da Conceição, M. L., De Paula Souza E Guimarães, R. J., … Lima, K. V. B. (2021). Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: A literature review. Memorias Do Instituto Oswaldo Cruz, 116(1). https://doi.org/10.1590/0074-02760200517
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