ECG changes in birth asphyxia and its correlation with Cardiac troponin-I

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 315005287 ECG correlation - I Article CITATIONS 0 READS 33 2 , including : Manjusha Gandhi 17 SEE All . Abstract Introduction :Cardiacdysfunctioniswellknowninperinatalasphyxiacausedbytransitmyocardialischemia.Sometimescardiacdysfunctionmaybesoseverethatitcancausecongestivecardiacfailureandshockthatleadstodeathofnewborn.ECGandserumlevelsofcardiacenzymescanbeusedtodemonstrateimpairedmyocardialfunction.MaterialandMethods:Itwasacasecontrolstudyconductedinthedepartmentofpaediatrics,GandhiMedicalCollege,Bhopaloveraperiodof12monthsfromJanuary2013toDecember2013.Fortyasphyxiatedfulltermneonatesweretakenascasesand20healthyfulltermneonatesascontrols.FortyneonateswithasphyxiaadmittedtoNICUwithgestationalage>37completedweeksandwithbirthweight>2kgtakenascasesandtwentyhealthyfulltermneonates(37completedwks)unasphyxiatedweighing>2kgatbirthwithclearliquorand1minApgarscore>7.Results:Myocardialdysfunctionwaspresentin90%ofthenewbornswithseverebirthasphyxiaand40%ofnewbornswithmoderatebirthasphyxia.Twavechangeswereseenin80%neonateswithsevereasphyxiaand33%neonateswithmoderateasphyxia.Inpresentstudy,cTnIlevelsinseverelyasphyxiatedneonatesweresignificantlyhigherthanmoderatelyasphyxiatedneonatesandcontrolgroupneonates(4.6ng/ml,range2.1–7.8,and1.8ng/ml,range0.2–4.8ng/mland0.6ng/ml,range0.2-1ng/mlrespectively).Conclusion:Wefoundalinearrelationshipbetweenlevelsofcardiactroponin-Iandbirthasphyxia.Thereforecardiactroponin-Ilevelmaybeusefulinpredictingthemortalityandoutcomeinperinatalasphyxia.