Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence

Abstract

A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence. © 2008 Springer-Verlag.