Objective: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. Method: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. Results: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. Conclusion: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions.
CITATION STYLE
Fragoso, Y. D., Finkelsztejn, A., Gomes, S., Kaimen-Maciel, D. R., Oliveira, C. L., Lopes, J., & Cristovam, A. R. (2011). Restless legs syndrome and multiple sclerosisa Brazilian multi center study and meta-analysis of the literature. Arquivos de Neuro-Psiquiatria, 69(2 A), 180–183. https://doi.org/10.1590/s0004-282x2011000200007
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