Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein

Abstract

Background: The mechanism for rapid biosynthesis of platelet-activating factor (PAF), a potent proinflammatory lipid mediator, is unclear. Results: Phosphorylation of lysophosphatidylcholine acyltransferase 2 (LPCAT2) at Ser-34 via PKCα enhanced rapid PAF biosynthesis following PAF or ATP stimulation. Conclusion: The molecular basis for rapid PAF biosynthesis in response to inflammatory stimuli is elucidated. Significance: These data suggest a better understanding of PAF production in early-phase inflammation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.