End-Diastolic and End-Systolic LV Morphology in the Presence of Cardiovascular Risk Factors: A UK Biobank Study

Abstract

Left ventricular function and morphology have been shown to be important factors in clinical and pre-clinical cardiovascular disease. In this paper we used atlas-based techniques to capture the full extent of morphological changes at end-diastole, end-systole and in a coupled functional atlas for 4547 UK Biobank participants. The morphological differences between participants with risk factors for cardiovascular disease were tested using a logistic regression model. The result was compared to a model built from traditional mass and volume measures, and the strength of associations were tested using a Delong’s test. Atlas based models had stronger associations with risk factors than mass and volume parameters in most risk factors. The functional atlas showed better performance than the separate end-diastole and end-systole atlases.