Relationship between interpersonal sensitivity and leukocyte telomere length

Abstract

Background: Telomeres are repetitive DNA sequences located at the ends of chromosomes, and telomere length represents a biological marker for cellular aging. Interpersonal sensitivity, excessive sensitivity to the behavior and feelings of others, is one of the vulnerable factors to depression. In the present study, we examined the effect of interpersonal sensitivity on telomere length in healthy subjects. Methods: The subjects were 159 unrelated healthy Japanese volunteers. Mean age±SD (range) of the subjects was 42.3±7.8 (30-61) years. Interpersonal sensitivity was assessed by the Japanese version of the Interpersonal Sensitivity Measure (IPSM). Leukocyte telomere length was determined by a quantitative real-time PCR method. Results: Higher scores of the total IPSM were significantly (β=-0.163, p=0.038) related to shorter telomere length. In the sub-scale analysis, higher scores of timidity were significantly (β=-0.220, p=0.044) associated with shorter telomere length. Conclusions: The present study suggests that subjects with higher interpersonal sensitivity have shorter leukocyte telomere length, implying that interpersonal sensitivity has an impact on cellular aging.