Abstract
Chromatin is the combination of DNA and other proteins that make up the contents of the nucleus. Chromatin infl uences all DNAtemplated processes including transcription activation and repression, DNA replication and repair. It is now widely appreciated that perturbation of mechanisms regulating chromatin status may have a great impact on cellular physiopathology. In this chapter we describe some genetic diseases related to mutations in genes involved in regulation of chromatin status and also “acquired pathologies” ascribed to defects of ATP-dependent chromatin remodeling and histone post- translational modifications.
Author supplied keywords
- ATR-X and juberg marsidi syndrome
- Chromatin structure and diseases
- Histone acetyltransferases (HAT)
- ICF syndrome and DNA methylation
- Mesenchymal stem cell (MSC)
- Rubinstein taybi syndrome and histone acetylation
- Schimke immunoosseous dysplasia
- Senescence and cancer
- Sutherland-haan and smith fi neman myers syndrome
- Williams syndrome
Cite
CITATION STYLE
Galderisi, U., & Peluso, G. (2014). Defects in chromatin structure and diseases. In Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies (pp. 143–153). Springer Netherlands. https://doi.org/10.1007/978-94-007-7726-2_15
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