Cytokines in experimental autoimmune encephalomyelitis

Abstract

The cytokine network governing the processes of inflammation, demyelination, relapses and recovery in EAE is very complex. Here we review the major proinflammatory and anti-inflammatory cytokines and their role in EAE, as shown by expression in nervous tissue, production by cells of the immune and nervous system, experiments with exogenous administration, overexpression, antibody neutralization or knockout mice.