Bilateral Risk-Reducing Mastectomies with Implant-Based Reconstructions Followed Long Term: A Consecutive Series of 185 Patients

7Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Bilateral risk-reducing mastectomy (BRRM) is the most effective method to prevent breast cancer in genetically predisposed women and is often performed concomitantly with breast reconstruction. The reconstruction time varies and corrective surgeries are common. Methods: This study evaluated 185 consecutive cases of BRRM and immediate breast reconstruction with implants with regard to surgical outcome and resource consumption. With an 18-year observation period, it was possible to compare permanent expander implants (PEIs) with permanent fixed volume implants (PIs). Results: A minimum follow-up of 2 years for all participants but one was achieved. Seventy-five percent (n = 138) of the women received PEI and 25% (n = 47) PI. In a multivariate analysis including age, BMI (<25, ≥25), smoking (yes, no), implant type (PEI, PI), incision technique, operation time and specimen weight <350 g, ≥350 g), only BMI ≥25 was associated with an increased risk of an early complication (OR 7.1, 95% CI 2.44–20.4). As expected, there was a significant difference in median reconstruction time between PEI and PI (12.4 vs. 1.0 months, p < 0.001). The cumulative reoperation-free 2-year survival was significantly higher in the PI than in the PEI group (81% vs. 26%, p < 0.001). Conclusion: Implant-based reconstruction remains a valid option after BRRM in high-risk women. Whenever possible (low BMI and small breast volume without severe ptosis), permanent fixed volume implants can be safely recommended and are resource saving in comparison with permanent expander implants.

References Powered by Scopus

Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: The PROSE study group

1055Citations
N/AReaders
Get full text

Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers

694Citations
N/AReaders
Get full text

Predicting complications following expander/implant breast reconstruction: An outcomes analysis based on preoperative clinical risk

396Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Prepectoral breast reconstruction: an ideal approach to bilateral risk-reducing mastectomy

17Citations
N/AReaders
Get full text

Risk-reducing mastectomy: a case series of 124 procedures in Brazilian patients

7Citations
N/AReaders
Get full text

Mental Illness and BRCA1/2 Genetic Testing Intention Among Multiethnic Women Undergoing Screening Mammography

6Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Isaksson, K., Arver, B., Bottai, M., Pettersson, A., Wickman, M., & Sandelin, K. (2019). Bilateral Risk-Reducing Mastectomies with Implant-Based Reconstructions Followed Long Term: A Consecutive Series of 185 Patients. World Journal of Surgery, 43(9), 2262–2270. https://doi.org/10.1007/s00268-019-05037-4

Readers over time

‘20‘21‘22‘23‘24036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

45%

Researcher 5

45%

Professor / Associate Prof. 1

9%

Readers' Discipline

Tooltip

Medicine and Dentistry 8

67%

Nursing and Health Professions 2

17%

Psychology 1

8%

Biochemistry, Genetics and Molecular Bi... 1

8%

Save time finding and organizing research with Mendeley

Sign up for free
0