Bile acids modulate reinstatement of cocaine conditioned place preference and accumbal dopamine dynamics without compromising appetitive learning

0Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Psychostimulants target the dopamine transporter (DAT) to elicit their psychomotor actions. Bile acids (BAs) can also bind to DAT and reduce behavioral responses to cocaine, suggesting a potential therapeutic application of BAs in psychostimulant use disorder. Here, we investigate the potential of BAs to decrease drug-primed reinstatement when administered during an abstinence phase. To do this, after successful development of cocaine-associated contextual place preference (cocaine CPP), cocaine administration was terminated, and animals treated with vehicle or obeticholic acid (OCA). When preference for the cocaine-associated context was extinguished, mice were challenged with a single priming dose of cocaine, and reinstatement of cocaine-associated contextual preference was measured. Animals treated with OCA demonstrate a significantly lower reinstatement for cocaine CPP. OCA also impairs the ability of cocaine to reduce the clearance rate of electrically stimulated dopamine release and diminishes the area under the curve (AUC) observed with amperometry. Furthermore, the AUC of the amperometric signal positively correlates with the reinstatement index. Using operant feeding devices, we demonstrate that OCA has no effect on contextual learning or motivation for natural rewards. These data highlight OCA as a potential therapeutic for cocaine use disorder.

References Powered by Scopus

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

4108Citations
N/AReaders
Get full text

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

2146Citations
N/AReaders
Get full text

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

1335Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zanella, D., Smith, N. K., Hardaway, J. A., Buchanan, A. M., Mullins, C. H., Galli, A., & Carter, A. M. (2023). Bile acids modulate reinstatement of cocaine conditioned place preference and accumbal dopamine dynamics without compromising appetitive learning. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-40456-3

Readers over time

‘23‘2402468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

67%

Lecturer / Post doc 1

33%

Readers' Discipline

Tooltip

Environmental Science 1

25%

Arts and Humanities 1

25%

Neuroscience 1

25%

Medicine and Dentistry 1

25%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0