Nonimmune-mediated drug-induced hepatotoxicity

Abstract

Although drug-mediated hepatotoxicity is of considerable importance and an important factor in the differential diagnosis of biochemical and structural liver disease, not much of its epidemiology in clinical practice is backed by high-quality data. It is assumed that the incidence of drug reactions leading to hepatic toxicity ranges from 1 in 10,000 to 1 in 100,000 of drug-exposed individuals or patients [1, 2].