A controlled, longitudinal study of dementia in Parkinson's disease

129Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Serial assessments of cognition, mood, and disability were carried out at nine month intervals over a 54 month period on a cohort of 87 patients with Parkinson's disease (PD) and a matched cohort of 50 control subjects. Dementia was diagnosed from data by rigorously applying DSM-III-R criteria. Initially, 6% (5/87) PD patients were demented, compared with none of the 50 control subjects. A further 10 PD patients met the dementia criteria during the follow up period; this was equivalent, with survival analysis, to a cumulative incidence of 19%. With the number of person years of observation as the denominator, the incidence was 47.6/1000 person years of observation. None of the control subjects fulfilled dementia criteria during the follow up period. The patients with PD who became demented during follow up were older at onset of Parkinson's disease than patients who did not become demented, had a longer duration of Parkinson's disease, and were older at inclusion to the study.

Cited by Powered by Scopus

Evolution of cognitive dysfunction in an incident Parkinson's disease cohort

783Citations
N/AReaders
Get full text

An algorithm (decision tree) for the management of Parkinson's disease (2001): Treatment guidelines

658Citations
N/AReaders
Get full text

Non-motor symptoms in Parkinson's disease

545Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Biggins, C. A., Boyd, J. L., Harrop, F. M., Madeley, P., Mindham, R. H. S., Randall, J. I., & Spokes, E. G. S. (1992). A controlled, longitudinal study of dementia in Parkinson’s disease. Journal of Neurology Neurosurgery and Psychiatry, 55(7), 566–571. https://doi.org/10.1136/jnnp.55.7.566

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

53%

Professor / Associate Prof. 4

24%

Researcher 3

18%

Lecturer / Post doc 1

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

37%

Psychology 5

26%

Agricultural and Biological Sciences 4

21%

Neuroscience 3

16%

Save time finding and organizing research with Mendeley

Sign up for free