Background: Clostridium perfringens toxin NetB is a key factor in avian necrotic enteritis. Results: NetB forms heptameric pores structurally similar to Staphylococcus aureus toxins but lacks a phosphocholine binding pocket. NetB activity is enhanced by cholesterol. Conclusion: NetB has distinct binding specificity, and cholesterol may act as a receptor. Significance: The structure of NetB will facilitate development of control measures against necrotic enteritis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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Savva, C. G., Da Costa, S. P. F., Bokori-Brown, M., Naylor, C. E., Cole, A. R., Moss, D. S., … Basak, A. K. (2013). Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens. Journal of Biological Chemistry, 288(5), 3512–3522. https://doi.org/10.1074/jbc.M112.430223