Adherens junctions are the most common junction type found in animal epithelia. Their core components are classical cadherins and catenins, which form membrane-spanning complexes that mediate intercellular binding on the extracellular side and associate with the actin cytoskeleton on the intracellular side. Junctional cadherin–catenin complexes are key elements involved in driving animal morphogenesis. Despite their ubiquity and importance, comparative studies of classical cadherins, catenins and their related molecules suggest that the cadherin/catenin-based adherens junctions have undergone structural and compositional transitions during the diversification of animal lineages. This chapter describes the molecular diversities related to the cadherin–catenin complex, based on accumulated molecular and genomic information. Understanding when and how the junctional cadherin–catenin complex originated, and its subsequent diversification in animals, promotes a comprehensive understanding of the mechanisms of animal morphological diversification.
CITATION STYLE
Oda, H. (2012). Evolution of the cadherin–catenin complex. Subcellular Biochemistry, 60, 9–35. https://doi.org/10.1007/978-94-007-4186-7_2
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