Candidate urinary biomarker discovery in gliomas

Abstract

Gliomas are the most common primary malignant brain tumors and have a very poor prognosis. Urine, which is not controlled by homeostatic mechanisms, can accumulate changes in the body and therefore is an ideal source for biomarker discovery. In this chapter, urine samples of animal models and glioma patients were investigated to identify candidate biomarkers of gliomas using proteomics analysis. The animal model was induced by injection of C6 cells in rat brain. Then rat urine samples were collected on days 2, 6, 10, and 13 after C6 cell inoculation. Urine samples from glioma patients were collected before and after tumor resection. Our results suggested that urinary proteins have potential as early sensitive biomarkers for detection and monitoring gliomas.