Trabectedin is a new marine-derived compound that binds the DNA minor groove and interacts with proteins of the DNA repair machinery. Phase I trials have established the standard regimen as 1500 μg/m2 24-hour continuous infusion repeated every 3 weeks. Several phase II trials have shown response in 5%-10% of unselected patients with soft tissue sarcoma failing prior chemotherapy and disease stabilisation in 30%-40%. Furthermore, prolonged disease control has been described in 15%-20% of patients. Toxicities are mainly haematological and hepatic with grade 3-4 neutropenia and thrombocytopenia observed in approximately 50% and 20% of patients respectively, and grade 3-4 elevation of liver enzymes observed in 35%-50% of patients treated with trabectedin. Current research focuses on the identification of predictive factors for patients with soft tissue sarcoma treated with trabectedin. © 2008 Dove Medical Press Limited. All rights reserved.
CITATION STYLE
Cassier, P. A., Dufresne, A., Blay, J. Y., & Fayette, J. (2008). Trabectedin and its potential in the treatment of soft tissue sarcoma. Therapeutics and Clinical Risk Management. https://doi.org/10.2147/tcrm.s1174
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