Signals Transduced through the CD4 Molecule on T-Lymphocytes Activate NF-κB

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Abstract

We have demonstrated that native envelope glycoproteins of HIV-1, gp160 can induce activation of the transcription factor, NF-κB. The stimulatory effects of gp160 are mediated through the CD4 molecule, since pretreatment with soluble CD4 abrogates its activity. The gp160-induced NF-κB complex consists of p65, p50 and c-rel proteins. The stimulatory effect of gp160 on NF-κB activation is protein synthesis independent, is dependent upon protein tyrosine phosphorylation, and abrogated by inhibitors of protein kinase C. The gp160-mediated activation of NF-κB in CD4 positive T cells may be involved in biological effects, e.g., enhanced HIV replication, hypergammaglobulinemia, increased cytokine secretion, hypercellularity in bone marrow and apoptosis. © 1994 Academic Press, Inc.

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Chirmule, N., Kalyanaraman, V. S., & Pahwa, S. (1994). Signals Transduced through the CD4 Molecule on T-Lymphocytes Activate NF-κB. Biochemical and Biophysical Research Communications, 203(1), 498–505. https://doi.org/10.1006/bbrc.1994.2210

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