Immunotherapy with heat shock protein 96 to treat gliomas

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Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment.

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Li, C., Du, Y., Zhang, Y., & Ji, N. (2020, September 3). Immunotherapy with heat shock protein 96 to treat gliomas. Chinese Neurosurgical Journal. BioMed Central.

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