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Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment.
Li, C., Du, Y., Zhang, Y., & Ji, N. (2020, September 3). Immunotherapy with heat shock protein 96 to treat gliomas. Chinese Neurosurgical Journal. BioMed Central. https://doi.org/10.1186/s41016-020-00211-3
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