Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above and beyond the changes seen in the aging of T-cell pool in the absence of TCE. This chapter discusses our current knowledge of the role of these expansions in health and disease, with a special focus on their influence upon immune defense against infectious diseases.
CITATION STYLE
Nikolich-Žugich, J., & Lang, A. (2009). Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (Vol. 9781402090639, pp. 219–233). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9_12
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