Immunotherapy has been growing in the past decade as a therapeutic alternative for cancer treatment. In this chapter, we deal with CAR-T cells, genetically engineered autologous T cells to express a chimeric receptor specific for an antigen expressed on tumor cell surface. While this type of personalized therapy is revolutionizing cancer treatment, especially B cell malignancies, it has some challenging limitations. Here, we discuss the basic immunological and technological aspects of CAR-T cell therapy, the limitations that have compromised its efficacy and safety, and the current proposed strategies to overcome these limitations, thereby allowing for greater therapeutic application of CAR-T cells.
CITATION STYLE
Picanço-Castro, V., Swiech, K., Malmegrim, K. C. R., & Covas, D. T. (2020). CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers. In Methods in Molecular Biology (Vol. 2086, pp. 1–10). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0146-4_1
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