Taxonomic Assignment in Metagenomics with TANGO

Abstract

One of the main computational challenges facing metagenomic analysis is the taxonomic identification of short DNA fragments. The combination of sequence alignment methods with taxonomic assignment based on consensus can provide an accurate estimate of the microbial diversity in a sample. In this note, we show how recent improvements to these consensus methods, as implemented in the latest release of the TANGO tool, can provide an improved estimate of diversity in simulated data sets.