Sequential inductions of the ZEB1 transcription factor caused by mutation of Rb and then Ras proteins are required for tumor initiation and progression

Abstract

Background: Ras mutation drives tumor initiation as well as invasion. Results: The ZEB1 transcription factor is sequentially induced with mutation of Rb1 and Ras, and these inductions are required for Ras-mediated tumor initiation and then invasion. Conclusion: ZEB1 plays a critical role in initiation and progression of Ras-mediated tumors. Significance: Induction ZEB1 is important for tumor initiation and invasion in a model of Ras-initiated cancer. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.