Curcumin, a strong natural compound with numerous health benefits, is extracted from the Curcuma longa. According to recent research findings, it also acts as a calorie restriction mimetic. We examined established aging biomarkers in erythrocytes and plasma and tested a persistent oral dietary dose of curcumin in young and d-galactose-induced accelerated rat aging models. For four weeks, d-gal (300 mg/kg b.w. subcutaneously) and curcumin (200 mg/kg b.w. oral) were administered simultaneously to test the protective effects of curcumin against d-galactose-induced accelerated aging and oxidative stress. In the accelerated senescent rat model, we discovered a significant rise in protein carbonyl, malonaldehyde (MDA), and advanced oxidation protein products. Increased levels of catalase, superoxide dismutase, ferric-reducing antioxidant potential, and reduced glutathione (GSH) were observed. Our findings reveal that curcumin has characteristics resembling a calorie restriction mimic and can successfully maintain redox equilibrium throughout the aging process in rat erythrocytes and plasma.
CITATION STYLE
Singh, A., Srivastava, P., Verma, A. K., Arya, J. K., & Rizvi, S. I. (2023). Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat. Biologia Futura, 74(1–2), 221–229. https://doi.org/10.1007/s42977-023-00170-7
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