Natural history of reflux oesophagitis: A 10 year follow up of its effect on patient symptomatology and quality of life

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Abstract

Background - Although oesophagitis is the most common diagnosis made at upper gastrointestinal endoscopy, data on the longterm outcome of affected patients are sparse. Aims - This study assessed the level of reflux symptoms, quality of life, drug consumption, and complications in patients at least 10 years after diagnosis of oesophagitis at one centre. Patients - One hundred and fifty two patients with typical reflux symptoms and a first time diagnosis by endoscopy of grade I-III oesophagitis between 1981 and 1984, were followed up using a postal questionnaire and telephone interview. Results - Eighteen of 152 patients had died, 33 failed to respond, and 101 replied (mean follow up 11 years, range 121-160 months). Over 70% of patients still had heartburn at least daily (32%) or weekly (19%) or required daily acid suppression treatment (20%). Two patients (2%) had developed oesophageal strictures and one had Barrett's oesophagus. Two of eight quality of life scores (physical function and social function) measured by the Short Form-36 were significantly lower than Northern Ireland population scores. Conclusion - Nearly three quarters of patients previously diagnosed as having oesophagitis still had significant morbidity related to gastro-oesophageal reflux disease more than 10 years after diagnosis. Some quality of life scores were significantly lower than those of the general population.

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McDougall, N. I., Johnston, B. T., Kee, F., Collins, J. S. A., McFarland, R. J., & Love, A. H. G. (1996). Natural history of reflux oesophagitis: A 10 year follow up of its effect on patient symptomatology and quality of life. Gut, 38(4), 481–486. https://doi.org/10.1136/gut.38.4.481

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