Virus infections have been linked to the induction of autoimmunity and disease development in human type 1 diabetes. Experimental models have been instrumental in deciphering processes leading to break of immunological tolerance and type 1 diabetes development. Animal models have also been useful for proof-of-concept studies and for preclinical testing of new therapeutic interventions. This chapter describes two robust and clinically relevant mouse models for virus-induced type 1 diabetes; acceleration of disease onset in prediabetic nonobese diabetic (NOD) mice following Coxsackievirus infection and diabetes induction by lymphocytic choriomeningitis virus (LCMV) infection of transgenic mice expressing viral neo-antigens under control of the rat insulin promoter (RIP).
CITATION STYLE
Christoffersson, G., & Flodström-Tullberg, M. (2020). Mouse Models of Virus-Induced Type 1 Diabetes. In Methods in Molecular Biology (Vol. 2128, pp. 93–105). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0385-7_7
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