We present a new, efficient algorithm for inferring, from time-series data or high-throughput data (e.g., flow cytometry), stochastic rate parameters for chemical reaction network models. Our algorithm combines the Gillespie stochastic simulation algorithm (including approximate variants such as tau-leaping) with the cross-entropy method. Also, it can work with incomplete datasets missing some model species, and with multiple datasets originating from experiment repetitions. We evaluate our algorithm on a number of challenging case studies, including bistable systems (Schlögl’s and toggle switch) and experimental data.
CITATION STYLE
Revell, J., & Zuliani, P. (2018). Stochastic Rate Parameter Inference Using the Cross-Entropy Method. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 11095 LNBI, pp. 146–164). Springer Verlag. https://doi.org/10.1007/978-3-319-99429-1_9
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