Experimental investigation to analyze cognitive impairment in diabetes mellitus

Abstract

Metabolic disorders and cognitive impairment are very common age-associated disorders. Alzheimer’s disease and diabetes are two common diseases and their possibility of occurrence increases as the age of a person increases. This paper proposes the percentage of type 2 diabetes patients that have a chance of developing Alzheimer’s disease. Pathophysiology and clinical patterns share common features in both the diseases as shown by epidemiological studies. There are a number of studies that show evidence of a connection between type 2 diabetes and Alzheimer’s disease but there is no proof of any biochemical mechanisms present yet. We focused our study and experiments on whether the alteration of factors like glycogen synthase kinase-3β activity, olfactory function, and ApoE genotypes can identify early cognitive impairment, which leads to Alzheimer’s disease.